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Istradefylline 40 mg/day improved peak amounts and AUC of CYP3A4 substrates in medical trials. This outcome wasn't noticed with istradefylline twenty mg/day. Take into consideration dose reduction of sensitive CYP3A4 substrates.fluvoxamine will raise the stage or impact of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contr